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Metal-free annulation/aerobic oxidative dehydrogenation of cyclohexanones...
Green Chemistry International Green Chem., 2016, Advance ArticleDOI: 10.1039/C6GC02396G, Communication Gopal Chandru Senadi, Ganesh Kumar Dhandabani, Wan-Ping Hu, Jeh-Jeng Wang We have identified...
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PF 06273340
PF-06273340 N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide CAS 1402438-74-7 Chemical Formula: C23H22ClN7O3...
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Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK...
(-)-32 as an off-white solid. Analytical data LCMS 418 [M+H]+1 H NMR (400 MHz, DMSO-d6) δ 8.23 (s, 1H), 6.88 (d, J = 8.0 Hz, 1H), 6.68 (s, 1H), 6.61 (dd,J = 11.2, 2.0 Hz, 1H), 6.49-6.38 (m, 2H), 6.33...
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ENHANCED ANALYTICAL METHOD CONTROL STRATEGY CONCEPT
DRUG REGULATORY AFFAIRS INTERNATIONAL ENHANCED ANALYTICAL METHOD CONTROL STRATEGY CONCEPT The benefits of quality by design (QbD) concepts related to both product (ICH Q8)1 and drug substance (ICH...
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Valdetamide
CAS Registry Number: 512-48-1 CAS Name: 2,2-Diethyl-4-pentenamide Additional Names: diethylallylacetamide Trademarks: Novonal (Hoechst) Molecular Formula: C9H17NO Molecular Weight: 155.24 Percent...
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Acetylcholine Chloride
Acetylcholine Chloride 2-acetyloxyethyl(trimethyl)azanium;chloride 60-31-1 Molecular Formula: C7H16ClNO2 Molecular Weight: 181.66 g/mol Acetylcholine chloride is obtained as white or off-white...
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New EDQM’s Public Document informs about the Details required in a New CEP...
DRUG REGULATORY AFFAIRS INTERNATIONAL A Policy Document recently published by the EDQM describes regulations for referencing already existing CEPs in an application for a new CEP. Read more about how...
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EMA/ FDA Mutual Recognition Agreement on drug facility inspections moving...
DRUG REGULATORY AFFAIRS INTERNATIONAL EMA/ FDA Mutual Recognition Agreement moving forward A possible agreement between the EMA and the US FDA on mutual recognition agreement on drug facility...
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Opportunities for Reducing Sampling and Testing of Starting Materials
DRUG REGULATORY AFFAIRS INTERNATIONAL Chapter 5 of the EC GMP Guide for the area of production was updated last year. This chapter contains concrete information about the conditions when testing and...
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New EDQM’s Public Document informs about the Details required in a New CEP...
DRUG REGULATORY AFFAIRS INTERNATIONAL A Policy Document recently published by the EDQM describes regulations for referencing already existing CEPs in an application for a new CEP. Read more about how...
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Now online – Stimuli article on the proposed USP General Chapter “The...
DRUG REGULATORY AFFAIRS INTERNATIONAL Now online – Stimuli article on the proposed USP General Chapter “The Analytical Procedure Lifecycle <1220>” A Stimuli Article to the Revision Process...
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Doxercalciferol, доксэркальциферол , دوكساركالسيفيرول , 度骨化醇
Doxercalciferol Molecular FormulaC28H44O2 Average mass412.648 доксэркальциферол [Russian] دوكساركالسيفيرول [Arabic] 度骨化醇 [Chinese] 1,3-Cyclohexanediol,...
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Generics: FDA´s New Guidance on Prior Approval Supplements
DRUG REGULATORY AFFAIRS INTERNATIONAL Generics: The US Food and Drug Administration (FDA) recently published a new Guidance regarding Prior Approval Supplements (PAS). Read more about FDA´s Guidance...
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Ranolazine Intermediate, An Efficient Synthesis of...
An efficient process for the preparation of 1-(2-methoxyphenoxy)-2,3-epoxypropane, a key intermediate for the synthesis of ranolazine is described. http://pubs.acs.org/doi/suppl/10.1021/op300056k...
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Designing Polymers for Amorphous Solid Dispersions — AAPS Blog
By: Laura I. Mosquera-Giraldo and Lynne S. Taylor Imagine spending billions of dollars in the discovery of a new drug, and then realizing that it is impractical to administer it orally because it...
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Lumefantrine
lumefantrine 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl]ethan-1-ol (±)-2,7-Dichloro-9-((Z)-p-chlorobenzylidene)-α-((dibutylamino)methyl)fluorene-4-methanol...
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Selection and justification of starting materials: new Questions and Answers...
DRUG REGULATORY AFFAIRS INTERNATIONAL The ICH Q11 Guideline describing approaches to developing and understanding the manufacturing process of drug substances was finalised in May 2012. Since then...
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Efficient atom and step economic (EASE) synthesis of the “smart drug” Modafinil
Green Chemistry International Efficient atom and step economic (EASE) synthesis of the “smart drug” Modafinil Green Chem., 2017, Advance ArticleDOI: 10.1039/C6GC02623K, Communication Shivam Maurya,...
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MODANAFIL
MODANAFIL Modafinil; 68693-11-8; Provigil; Modiodal; 2-[(diphenylmethyl)sulfinyl]acetamide; Modafinilum [Latin] Molecular Formula: C15H15NO2S Molecular Weight: 273.35 g/mol Patent EP0966962 and Patent...
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