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TR 700, TR 701FA, Tedizolid phosphate
“TR-700” 5R)-3-{3-Fluoro-4-[6-(2-methyl-2H-1,2,3,4-tetrazol-5-yl)-pyridin-3-yl]-phenyl}-5-hydroxymethyl-1,3-oxazolidin-2-one Trius Therapeutics, Inc. US Patent Publication No. 20070155798, which is...
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Genotoxic impurities: the new ICH M7 addendum to calculation of...
Originally posted on DRUG REGULATORY AFFAIRS INTERNATIONAL: Genotoxic impurities: the new ICH M7 addendum to calculation of compound-specific acceptable intakes The draft for a guideline ICH M7(R1)...
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New FDA Requirements for the Development of Herbal Medicinal Products
Originally posted on DRUG REGULATORY AFFAIRS INTERNATIONAL: The previous FDA guideline for herbal medicinal products from 2004 is supposed to be replaced by a new version. In August 2015, the FDA has...
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Efficacy and Safety of Olive in the Management of Hyperglycemia
Postprandial hyperglycemia indicates the abnormality in glucose turnover leading to the onset of type 2 diabetes. Therefore, correction of postprandial hyperglycemia is crucial in the early stage of...
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Defibrotide
Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic...
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SILDENAFIL
SILDENAFIL The chemical name of sildenafil is 5-[2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1- methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one and its formula is C22H30N6O4S. The...
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Merestinib
CAS 1206799-15-6 3-Pyridinecarboxamide, N-[3-fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-...
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BEXAGLIFLOZIN
Bexagliflozin THR1442; THR-1442, EGT 0001442; EGT1442 CAS :1118567-05-7 (2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[2- (cyclopropyloxy) ethoxy] phenyl} methyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-...
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Ciraparantag, Aripazine
Ciraparantag PER977， Aripazine CAS Number:1438492-26-2 Chemical Name:N1,N1-[piperazine-1,4-diylbis(propane-1,3-diyl)]bis-L-argininamide...
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EZETIMIBE POSTER
The synthesis of ezetimibe with high stereochemical purity Krzysztof Bańkowski , Katarzyna Sidoryk , Katarzyna Filip , Joanna Zagrodzka Pharmaceutical Research Institute (IF), Rydygiera 8,...
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Acceptability of Draft Labeling to Support ANDA Approval Guidance for Industry
Acceptability of Draft Labeling to Support ANDA Approval Guidance for Industry INTRODUCTION This guidance provides recommendations and information related to the submission of proposed labeling with...
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Synthesis of a fluorinated Ezetimibe analogue
Synthesis of a fluorinated Ezetimibe analogue using radical allylation of [small alpha]-bromo-[small alpha]-fluoro-[small beta]-lactam New J. Chem., 2015, Advance Article DOI: 10.1039/C5NJ01969A,...
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Sparsentan, PS433540, RE-021
Sparsentan(PS433540,RE-021) C32H40N4O5S Average mass592.749 4′-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2′-(ethoxymethyl)-[1,1′-biphenyl]-2-sulfonamide...
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Daprodustat, GSK1278863
Daprodustat, GSK1278863 960539-70-2 GSK1278863; GSK 1278863; GSK-1278863; Daprodustat C19H27N3O6 Exact Mass: 393.18999 (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine...
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Monoclonal Antibody Therapy: What is in the name or clear description?
Originally posted on Leaders in Pharmaceutical Business Intelligence: Monoclonal Antibody Therapy: What is in the name or clear description? Curator: Demet Sag, PhD, CRA, GCP What is in the name?...
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Etelcalcetide, AMG 416, KAI-4169, velcalcetide
H-L-Cys-OH S— S Ac-D-Cys-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2 AMG 416 IS (Ac-D-Cys(L-Cys-OH)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2) Etelcalcetide (AMG 416, KAI-4169, velcalcetide) The main chain...
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VARDENAFIL
VARDENAFIL 224785-90-4 CAS NO Vardenafil hydrochloride (CAS NO.224785-91-5) Formula C23H32N6O4S Mol. mass 488.604 g/mol...
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Ribociclib
Ribociclib Ribociclib (LEE011) CAS: 1211441-98-3 Chemical Formula: C23H30N8O Exact Mass: 434.25426 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid...
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Abemaciclib (Bemaciclib)
Abemaciclib (Bemaciclib) N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine 2-Pyrimidinamine,...
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Pramipexole
Pramipexole, (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole, represented by the following formula I (the compound of formula I), is a dopamine D2/D3 agonist used for treatment of...
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